C21, M72
ENEA Technology
INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT: DEVELOPMENT OF NEW BIOMARKERS AND MEDICAL DEVICES IN A PUBLIC-PRIVATE NETWORK
Technology Readiness Level (TRL)
6÷7
Innovations and Benefits
Identification and characterization of novel biomarkers of chronic inflammatory disorders of gastrointestinal tract in substitution of highly invasive and expensive diagnostic methods. Identification and characterization of medical devices (molecules having no pharmacological nature) to be used for the treatment of inflammatory intestinal and extra-intestinal diseases in order to reduce the use of highly toxic drugs.
Use
- Development of diagnostic and prognostic kit to commercialize;
- development of medical devices to commercialize in place of or alongside the pharmacological therapies.
Applications and ongoing Activities
Many chronic inflammatory diseases, in particular those involving the gastrointestinal tract, are in great increase in recent years, especially in children. They involve the use of drugs with important side effects. Studies are in progress, in collaboration with the Department of Pediatrics and Neuropsychiatry and the Department of Cellular Biotechnology and Hematology of the University of Rome Sapienza and with national Companies (Italchimici SPA, DMG Srl, Italdevice Srl) aimed at identifying and characterizing molecules with strong antiinflammatory properties, but without side effects on health of the patient, which may be used in addition to and replacement to conventional therapies. Another field of study concerns the identification of faecal biomarkers of inflammation, to be used for diagnosis and monitoring chronic inflammatory bowel disease, replacing the current highly invasive diagnostic methods. In the past, proteins considered good biomarkers of intestinal inflammation (HMGB1) and molecules with marked anti-inflammatory activity (glycyrrhetinic acid, krill oil) have been identified.
“If you are interested in this technology/service, please send a message to eneaperlinnovazione@enea.it, by specifying the title of the technology/service of your interest, the reason for your request and your contacts or the contacts of a person from your organization/company.
